The aim of the study was to evaluate the antihypoxic and antioxidant effect of Cytochrome-C in patients with craniocerebral trauma (CCT). Material and methods: We examined 167 children with traumatic brain injury (TBI) and with concussion of the brain at the age of 6 months to 14 years old, hospitalized in the ICU 2 – SamMI clinic. Children with TBI were divided into two groups. Patients of group 1 (87) underwent standard treatment. Group 2 (80) consisted of patients who were additionally given a continuous intramuscular injection of Cytochrome-C in the calculation of 1 mg / kg per day for 10-12 days of their presence in the clinic. Patients underwent a general neurologic examination, dynamic observation and a set of studies , neurosonography was performed for a patient up to a year, EEG for patients with CCI with convulsions, MSCT and MRI for severe TBI, in the 1st day of hemoglobin in the blood, and detailed biochemical analysis blood. Results: With standard infusion and transfusion therapy, the improvement was for 5 days, and against a background of constant injection of Cytochrome-C, compensation mechanisms are implemented on the third day of treatment, and on the 5th day of the post-traumatic period oxygen balance is normalized, and antioxidant protection of brain tissue. Restoration of oxygen balance in patients protected by Cytochrome-C, mainly due to the normalization of pumping function of the heart. Correction of oxygen debt was accompanied by a decrease in the level of lactate and glucose. All this makes it possible to recommend the inclusion of Cytochrome-C in the standards of intensive treatment of victims with trauma to the skull and concussion of the brain. Conclusion: The inclusion of Cytochrome-C in the complex treatment of patients with CCI contributes to early recovery of oxygen balance and correction of metabolic disorders and rapid recovery of patients.